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Anti-STAT1 Rabbit mAb

Anti-STAT1 Rabbit mAb

Item no.	PTM-5754
Manufacturer	PTM Biolabs
Amount	100 ul
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Format	Lyophilized powder
Applications	WB, IP, IHC-P
Clone	JRMR-10313-20
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	Xu Meng-Meng, et al. Melatonin improves influenza virus infection-induced acute exacerbation of COPD by suppressing macrophage M1 polarization and apoptosis. RESPIRATORY RESEARCH, 2024. https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-024-02815-0.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Signal transducer and activator of transcription 1,Stat1
Shipping Condition	Room temperature
Available
Manufacturer - Type	Primary Antibodies
Manufacturer - Category	Uncategorized
Manufacturer - Targets	STAT1
Shipping Temperature	Ambient temperature
Storage Conditions	Store at -20°C. Avoid freeze/thaw cycles.
Stability	Stable for 12 months from date of receipt/reconstitution.
Manufacturer - Research Area	Cancer
Product description	Signal transducer and activator of transcription 1 (STAT1) is an important protein that connects cell membrane receptors and effectors for signal transduction. STAT1 is activated by tyrosine kinase (JAK) and mitogen-activated protein kinases (MAPK) to phosphorylate the conserved tyrosine and serine residues in the C-terminal activation region to form a dimer After translocation enters the nucleus and regulates target genes, its main signaling pathway is dependent on the interferon (IFN) signaling pathway. STAT1 is highly expressed in normal human brain tissues, but is low or not expressed in human glioma tissues. STAT1 has an inhibitory effect on gliomas, mainly by promoting cell apoptosis, inhibiting cell proliferation, negatively regulating the cell cycle, inhibiting tumor angiogenesis, and reducing tumor migration and invasion capabilities. In some tumors, the excessive activation of STAT1 does not induce tumor cell apoptosis, but promotes tumor cell proliferation and drug resistance.
Purification Method	Protein A purified
Formula	PBS, Glycerol, BSA
PTM	Unmodified
Clonality	Recombinant Monoclonal
Background	Signal transducer and activator of transcription 1 (STAT1) is an important protein that connects cell membrane receptors and effectors for signal transduction. STAT1 is activated by tyrosine kinase (JAK) and mitogen-activated protein kinases (MAPK) to phosphorylate the conserved tyrosine and serine residues in the C-terminal activation region to form a dimer After translocation enters the nucleus and regulates target genes, its main signaling pathway is dependent on the interferon (IFN) signaling pathway. STAT1 is highly expressed in normal human brain tissues, but is low or not expressed in human glioma tissues. STAT1 has an inhibitory effect on gliomas, mainly by promoting cell apoptosis, inhibiting cell proliferation, negatively regulating the cell cycle, inhibiting tumor angiogenesis, and reducing tumor migration and invasion capabilities. In some tumors, the excessive activation of STAT1 does not induce tumor cell apoptosis, but promotes tumor cell proliferation and drug resistance.
Cellular Localization	Cytoplasm, Nucleus

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 2/19/2026

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