Anti-S100A1 Rabbit mAb

WB, IHC-P, ICC/IF, FC

S100A1

Store at -20°C. Avoid freeze/thaw cycles.

Stable for 12 months from date of receipt/reconstitution.

S100A1 is a member of the S100 protein family, each of which contains two EF-hand calcium-binding motifs. These proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. At least 13 S100 genes are clustered on chromosome 1q21. S100A1 may function in stimulation of Ca²⁺-induced Ca²⁺ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. 

Anti-S100A1 Rabbit mAb detects endogenous levels of total S100A1 protein.

Unmodified

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies.