Anti-MCM7 Rabbit mAb

Uncategorized

Store at -20°C. Avoid freeze/thaw cycles.

Anti-MCM7 Rabbit mAb

PBS, Glycerol, BSA

Recombinant Monoclonal

DNA replication licensing factor MCM7 acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for once per cell cycle DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. MCM7 is also required for S-phase checkpoint activation upon UV-induced damage.