Anti-Topoisomerase I Rabbit mAb

WB, IHC-P, ICC/IF, FC, IP

Topoisomerase I

Store at -20°C. Avoid freeze/thaw cycles.

Stable for 12 months from date of receipt/reconstitution.

DNA topoisomerases play essential roles in many DNA metabolic processes including DNA repair. Topoisomerases can introduce DNA damage upon exposure to drugs that stabilize the covalent protein-DNA intermediate of the topoisomerase reaction. Lesions in DNA are also able to trap topoisomerase-DNA intermediates. DNA topoisomerase I (Top1) catalyzes the relaxation of supercoiled DNA by a mechanism of transient DNA strand cleavage characterized by the formation of a phosphotyrosyl bond between the DNA end and active site tyrosine.

Anti-Topoisomerase I Rabbit mAb recognizes endogeneous level of Topoisomerase I protein.

Unmodified

Recombinant Monoclonal

Cell nucleus