Anti-GNMT Mouse mAb

Uncategorized

Store at -20°C. Avoid freeze/thaw cycles.

Anti-GNMT Mouse mAb

PBS, Glycerol, BSA

Recombinant Monoclonal

Glycine N-methyltransferase(GNMT) is an enzyme that is encoded by the GNMT gene in human. GNMT catalyzes the synthesis of N-methylglycine (sarcosine) from glycine using S-adenosylmethionine(SAM) (AdoMet) as the methyl donor. GNMT acts as an enzyme to regulate the ratio of S-adenosylmethionine(SAM) to S-adenosylhomocysteine (SAH) (AdoHcy) and participates in the detoxification pathway in liver cells. GNMT competes with tRNA methyltransferases for SAM and the product, S-adenosylhomocysteine (SAH), is a potent inhibitor of tRNA methyltransferases and a relatively weak inhibitor of GNMT. GNMT regulates the relative levels of SAM and SAH. Since SAM is the methyl donor for almost all cellular methylation reactions. GNMT is therefore likely to regulate cellular methylation capacity.