Anti-IRF8 Mouse mAb

Uncategorized

Store at -20°C. Avoid freeze/thaw cycles.

Anti-IRF8 Mouse mAb

PBS, Glycerol, BSA

Recombinant Monoclonal

IRF-8 is a member of Interferon regulatory factors family, which is expressed predominately in hematopoietic cells and is further increased upon treatment with interferon. IRF-8 can function as a transcription repressor of ICS-containing promoters. Expression of IRF-8 can lead to the downregulation of the anti-apoptotic protein Bcl-2. Originally described as being induced by IFN-γ, IRF-8 expression is also elevated by IRF-α as well as IL-12 in NK and T cells. IRF-8 deficient mice have enhanced susceptibility to various pathogens and impaired production of interferons, as well as deregulated hematopoiesis that resembles chronic myelogenous leukemia. IRF-8 also regulates bone metabolism by suppressing osteoclast formation.