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Anti-beta-Arrestin 1 Mouse mAb

Anti-beta-Arrestin 1 Mouse mAb

Item no.	PTM-6445
Manufacturer	PTM Biolabs
Amount	100 ul
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Format	Lyophilized powder
Applications	WB, ICC, IHC-P
Clone	JMMR-2675
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Mouse
Isotype	IgG2a
Conjugate/Tag	Unconjugated
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	ARRB1,ARR1
Shipping Condition	Room temperature
Available
Manufacturer - Type	Primary Antibodies
Manufacturer - Applications	WB, IHC-P, ICC/IF
Manufacturer - Category	Uncategorized
Manufacturer - Targets	beta-Arrestin 1
Shipping Temperature	Ambient temperature
Storage Conditions	Store at -20°C. Avoid freeze/thaw cycles.
Stability	Stable for 12 months from date of receipt/reconstitution.
Manufacturer - Research Area	Signal Transduction, Neuroscience
Product description	Beta-Arrestin 1 is one of β-Arrestins (ARRBs), the best-known negative regulators of G protein-coupled receptor signaling. β-Arrestins are versatile and multifunctional adapter proteins that regulate diverse cellular functions, including cell growth, apoptosis and immune responses. Overexpression of beta-Arrestin 1 has been found in various cancers, indicating it is a potential therapeutic target for cancer treatment. Recently, expression of beta-Arrestin 1 in saliva has been identified as a candidate circadian biomarker. Erk1/2 constitutively phosphorylates beta-Arrestin 1 at carboxy-terminal Ser412, which promotes cytosolic localization of the scaffold protein. Dephosphorylation is an essential step of beta-Arrestin 1-mediated receptor endocytosis, but it is not required for receptor desensitization.
Purification Method	Protein A purified
Formula	PBS, Glycerol, BSA
PTM	Unmodified
Clonality	Recombinant Monoclonal
Background	Beta-Arrestin 1 is one of β-Arrestins (ARRBs), the best-known negative regulators of G protein-coupled receptor signaling. β-Arrestins are versatile and multifunctional adapter proteins that regulate diverse cellular functions, including cell growth, apoptosis and immune responses. Overexpression of beta-Arrestin 1 has been found in various cancers, indicating it is a potential therapeutic target for cancer treatment. Recently, expression of beta-Arrestin 1 in saliva has been identified as a candidate circadian biomarker. Erk1/2 constitutively phosphorylates beta-Arrestin 1 at carboxy-terminal Ser412, which promotes cytosolic localization of the scaffold protein. Dephosphorylation is an essential step of beta-Arrestin 1-mediated receptor endocytosis, but it is not required for receptor desensitization.
Cellular Localization	Nucleus, Cytoplasm, Plasma membrane

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 2/19/2026

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