Anti-ZO-2 Mouse mAb

Organelle Marker Antibodies

Ambient temperature

Stable for 12 months from date of receipt/reconstitution.

ZO-2 is a member of Zona occludens proteins (ZO-1, -2, and -3), which are peripheral membrane adaptor proteins that link junctional transmembrane proteins, such as occludin and claudin, to the actin cytoskeleton. ZO-1 and -2 are required for tight junction formation and function. In sub-confluent proliferating cells, ZO-1 and ZO-2 have been shown to colocalize to the nucleus and play a role in transcriptional regulation, possibly through facilitating nuclear import/export of transcriptional regulators. The ZO-2 gene is transcribed from two promoters, generating the ZO-2A and ZO-2C isoforms. ZO-2C lacks a 23 amino acid amino-terminal sequence found in other ZO-2 isoforms. While both isoforms appear to be widely expressed, abnormal regulation of the ZO-2 gene may be correlated with development of ductal cancer.

PBS, Glycerol, BSA

Recombinant Monoclonal

Cytosol, Nucleus