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Anti-Legumain Mouse mAb

Anti-Legumain Mouse mAb

Item no.	PTM-6596
Manufacturer	PTM Biolabs
Amount	100 ul
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Format	Lyophilized powder
Applications	WB, IHC-P
Clone	JMMR-2051
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Mouse
Isotype	IgG1
Conjugate/Tag	Unconjugated
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	LGMN,PRSC1,Asparaginyl endopeptidase
Shipping Condition	Room temperature
Available
Manufacturer - Type	Primary Antibodies
Manufacturer - Category	Uncategorized
Manufacturer - Targets	Legumain
Shipping Temperature	Ambient temperature
Storage Conditions	Store at -20°C. Avoid freeze/thaw cycles.
Stability	Stable for 12 months from date of receipt/reconstitution.
Manufacturer - Research Area	Immunology, Cell Biology, Signal Transduction, Cancer, Metabolism
Product description	Legumain (LGMN) is an asparaginyl endopeptidase that mediates lysosomal processing of antigen for class II MHC presentation. Under normal conditions, LGMN is mostly found in lysosomes. However, its expression level, cellular compartmentalization, and function may change under certain conditions, including cancer. In colorectal cancer, LGMN is upregulated and is found extracellularly and in the nucleus in both primary tumors and colorectal cancer cell lines. Legumain forms homodimers and may be activated by posttranslational modifications, including autoproteolytic cleavage, as it moves from one cellular compartment to another.
Purification Method	Protein A purified
Formula	PBS, Glycerol, BSA
PTM	Unmodified
Clonality	Recombinant Monoclonal
Background	Legumain (LGMN) is an asparaginyl endopeptidase that mediates lysosomal processing of antigen for class II MHC presentation. Under normal conditions, LGMN is mostly found in lysosomes. However, its expression level, cellular compartmentalization, and function may change under certain conditions, including cancer. In colorectal cancer, LGMN is upregulated and is found extracellularly and in the nucleus in both primary tumors and colorectal cancer cell lines. Legumain forms homodimers and may be activated by posttranslational modifications, including autoproteolytic cleavage, as it moves from one cellular compartment to another.
Cellular Localization	Lysosome

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 2/19/2026

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