Anti-PAX5 Rabbit mAb

Primary Antibodies

PAX5

Store at -20°C. Avoid freeze/thaw cycles.

Stable for 12 months from date of receipt/reconstitution.

PAX5, also known as B cell-specific activator protein (BSAP), was originally identified as a DNA-binding protein with affinity for both immunoglobulin heavy-chain and kappa light-chain loci. PAX5 is unique within the PAX family in being the only member with reported expression in the hematopoietic system. PAX5 is required to promote differentiation of common lymphoid progenitors (CLPs) into B cells; it is also required for the continued maintenance of B cell identity following differentiation. Disruptions to the expression of PAX5 have consequently been linked with lymphoid cancer development.

Anti-PAX5 Rabbit mAb recognizes endogeneous level of PAX5 protein.

Unmodified

PAX5, also known as B cell-specific activator protein (BSAP), was originally identified as a DNA-binding protein with affinity for both immunoglobulin heavy-chain and kappa light-chain loci. PAX5 is unique within the PAX family in being the only member with reported expression in the hematopoietic system. PAX5 is required to promote differentiation of common lymphoid progenitors (CLPs) into B cells; it is also required for the continued maintenance of B cell identity following differentiation. Disruptions to the expression of PAX5 have consequently been linked with lymphoid cancer development.