Anti-LRP6 Rabbit mAb

Uncategorized

Ambient temperature

Stable for 12 months from date of receipt/reconstitution.

LRP6 is a single-pass transmembrane protein belonging to the low-density lipoprotein receptor (LDLR)-related protein family. Unlike other members of the LDLR family, LRP6 has four EGF and three LDLR repeats in the extracellular domain, and proline-rich motifs in the cytoplasmic domain. It functions as co-receptors for Wnt and is required for the canonical Wnt/β-catenin signaling pathway. LRP6 is highly homologous and has redundant roles during development. The activity of LRP6 can be inhibited by the binding of some members of the Dickkopf (DKK) family of proteins. Upon stimulation with Wnt, LRP6 is phosphorylated at multiple sites including Thr1479, Ser1490, and Thr1493 by kinases such as GSK-3 and CK1. Phosphorylated LRP6 recruits axin to the membrane and presumably activates β-catenin signaling.

PBS, Glycerol, BSA

Recombinant Monoclonal

Endoplasmic reticulum, Membrane