Anti-Phospho-AKT (Thr308) Rabbit mAb

Uncategorized

Ambient temperature

Stable for 12 months from date of receipt/reconstitution.

Akt, also referred to as PKB or Rac, plays a critical role in controlling survival and apoptosis. This protein kinase is activated by insulin and various growth and survival factors to function in a wortmannin-sensitive pathway involving PI3 kinase. AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Phosphorylation on Thr-308, Ser-473 and Tyr-474 of AKT are required for its full activity. AKT1 Thr-308 and Ser-473 is Phosphorylated by IKBKE and TBK1.

PBS, Glycerol, BSA

Thr308

Akt, also referred to as PKB or Rac, plays a critical role in controlling survival and apoptosis. This protein kinase is activated by insulin and various growth and survival factors to function in a wortmannin-sensitive pathway involving PI3 kinase. AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Phosphorylation on Thr-308, Ser-473 and Tyr-474 of AKT are required for its full activity. AKT1 Thr-308 and Ser-473 is Phosphorylated by IKBKE and TBK1.