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Anti-Iba1/AIF-1 Rabbit mAb

Anti-Iba1/AIF-1 Rabbit mAb

Item no.	PTM-7108
Manufacturer	PTM Biolabs
Amount	100 ul
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Format	Lyophilized powder
Applications	IHC-P
Clone	JRMR-10822-53B
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	AIF1,G1
Shipping Condition	Room temperature
Available
Manufacturer - Type	Primary Antibodies
Manufacturer - Applications	IHC-P, mIHC-P
Manufacturer - Category	Uncategorized
Manufacturer - Targets	Iba1 / AIF-1
Shipping Temperature	Ambient temperature
Storage Conditions	Store at -20°C. Avoid freeze/thaw cycles.
Stability	Stable for 12 months from date of receipt/reconstitution.
Manufacturer - Research Area	Cell Biology, Immunology, Neuroscience, Metabolism, Signal Transduction
Product description	Ionized calcium-binding adaptor molecule 1 (Iba1), also known as allograft inflammatory factor 1 (AIF-1), is an evolutionarily conserved cytoplasmic calcium binding protein containing a central pair of EF-hand calcium binding motifs.Iba1 was originally cloned from activated macrophages in human atherosclerotic allogenic heart grafts undergoing chronic transplant rejection as well as from rat monocytes. Its function is not very well understood, but Iba1 expression is upregulated in response to interferon-gamma and, therefore, could modulate macrophage-dependent immune response. As an F-actin-binding protein, Iba1 may function to remodel the actin cytoskeleton and contribute to morphological changes that correlate with various microglial/macrophage states. Iba1 is also uniquely expressed in cells of monocytic lineage and is, therefore, widely used as a marker for microglia/macrophages in the brain and other tissue.
Purification Method	Protein A purified
Formula	PBS, Glycerol, BSA
PTM	Unmodified
Clonality	Recombinant Monoclonal
Background	Ionized calcium-binding adaptor molecule 1 (Iba1), also known as allograft inflammatory factor 1 (AIF-1), is an evolutionarily conserved cytoplasmic calcium binding protein containing a central pair of EF-hand calcium binding motifs.Iba1 was originally cloned from activated macrophages in human atherosclerotic allogenic heart grafts undergoing chronic transplant rejection as well as from rat monocytes. Its function is not very well understood, but Iba1 expression is upregulated in response to interferon-gamma and, therefore, could modulate macrophage-dependent immune response. As an F-actin-binding protein, Iba1 may function to remodel the actin cytoskeleton and contribute to morphological changes that correlate with various microglial/macrophage states. Iba1 is also uniquely expressed in cells of monocytic lineage and is, therefore, widely used as a marker for microglia/macrophages in the brain and other tissue.
Cellular Localization	Cytoplasm, Cytoskeleton

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 2/19/2026

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