Anti-CTCFL Rabbit mAb

Uncategorized

Ambient temperature

75

Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts byrecruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment ofdifferential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNAmethyltransferases at these sites. Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation ofBAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters

PBS, Glycerol, BSA

Recombinant Monoclonal