BCL6, CT (BCL6, BCL5, LAZ3, ZBTB27, ZNF51, B Cell lymphoma 6 protein, B Cell lymphoma 5 protein, Protein LAZ-3, Zinc finger and BTB domain-containing protein 27, Zinc finger protein 51)

Antibodies / Antibodies-Transcription Factors, Zinc (Ring) Finger

-20°C

Supplied as a liquid, 0.09% sodium azide.

BCL6 Mab is generated from mouse immunized with BCL6 recombinant protein.

The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

Applications:
Suitable for use in Western Blot, Immunofluorescence, ELISA.

Recommended Dilution:
ELISA: 1:1000
Western Blot: 1:1000~16000
Immunofluorescence: 1:10~50

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.