BCL10,NT (BCL10,CIPER,CLAP,B Cell lymphoma/leukemia 10,B Cell CLL/lymphoma 10,CARD-containing molecule enhancing NF-kappa-B,CARD-like apoptotic protein,CED-3/ICH-1 prodomain homologous E10-like regulator,Cellular homolog

Antibodies / Antibodies-Cancer Markers, Leukemia

-20°C

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 24-51 in the N-terminal region of human BCL10, UniProt Accession #O95999. Species sequence homology: rat

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

Applications:
Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, Indirect Flow Cytometry and ELISA. Other applications have not been tested.

Recommended Dilution:
Western Blot: 1:1000
Immunohistochemistry (FFPE): 1:50-1:100
Immunofluorescence: 1:10-1:50
Indirect Flow Cytometry: 1:10-1:50
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.