Ptk2b,ID (Ptk2b,Fak2,Pyk2,Raftk,Protein-tyrosine kinase 2-beta,Calcium-dependent tyrosine kinase,Calcium-regulated non-receptor proline-rich tyrosine kinase,Cell adhesion kinase beta,Focal adhesion kinase 2,Proline-rich

Antibodies / Antibodies-Protein Kinases

-20°C

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Mouse Ptk2b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 671-701 amino acids from the Central region of Mouse Ptk2b.

Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation (By similarity).

Applications:
Suitable for use in Western Blot, Immunohistochemistry, ELISA

Recommended Dilution:
ELISA: 1:1, 000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.