Sox2, phosphorylated (S246) (SOX2, Transcription factor SOX-2)

Antibodies / Antibodies-Transcription Factors

-20°C

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

KLH-conjugated synthetic phospho-peptide mapping to a fragment of residues surrounding S246 of human Sox2, UniProt Accession #P48431. Species sequence homology: mouse

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).

Applications:
Suitable for use in Immunofluorescence, Dot Blot and ELISA. Other applications not tested.

Recommended Dilution:
Immunofluorescence: 1:200
Dot blot: 1:500
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.