TLR3, CT

Antibodies / Antibodies-Toll Like Receptors (TLR)

-20°C

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

TLR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 754ca.783 amino acids from the C-terminal region of human TLR3.

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.

Applications:
Suitable for use in Immunohistochemistry, ELISA

Recommended Dilution:
ELISA: 1:1, 000
Immunohistochemistry: 1:50-100

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.