Vitronectin Receptor (CD51, Cluster of Differentiation 51, Integrin aV)

Antibodies / Antibodies-CD Markers

-20°C

Supplied as a liquid in PBS, 0.09% sodium azide.

Human melanoma metastasis.

CD51 (Cluster of Differentiation 51), known as vitronectin receptor a chain, or integrin aV is a type I integral membrane glycoprotein. CD51 forms a heterodimer with integrin b1 (CD29), b3 (CD61), b5, b6, or b8. CD51 contains two disulfide-linked subunits of 125 kD and 24 kD. Many extracellular matrix proteins with RGD-motifs are CD51 ligands. In association with its b chains, CD51 binds vitronectin, von Willebrand factor, fibronectin, thrombospondin, osteopontin, fibrinogen, and laminin. CD51, as an adhesion molecule, plays important roles in leukocytes homing and rolling, mediates bone absorption and angiogenesis. CD51 is expressed on endothelial cells, fibroblasts, macrophages, platelets, osteoclasts, neuroblastoma, melanoma, and hepatoma cells.

Applications:
Suitable for use in ELISA, Immunofluorescence, Immunoprecipitation and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Hybridoma:
Sp2/0 myeloma cells with spleen cells from Balb/c mice.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.