Bcl10 (B Cell CLL/lymphoma 10,B Cell lymphoma/leukemia 10,CARD-containing Molecule Enhancing NF-kappa-B,CARD-like apoptotic protein,CARMEN,cCARMEN,c-E10,CED-3/ICH-1 prodomain homologous E10-like regulator,Cellular-E10,Ce

Antibodies / Antibodies-Apoptosis

-20°C

Supplied as a liquid, 0.03% sodium azide.

Purified recombinant fragment of human BCL-10 expressed in E. coli.

Bcl-10 (B-cell CLL/lymphoma 10), also known as CLAP, Me10, CIPER, c-E10, CARMEN. Entrez Protein NP_003912. It is a protein containing a caspase recruitment domain (CARD). It plays an important role in apoptosis and activating NF-kappaB. The research suggested that it interacted with other CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-kappaB signaling. Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

Applications:
Suitable for use in Flow Cytometry, ELISA, Western Blot, Immunohistochemistry and Immunocytochemistry.
Other applications not tested.

Recommended Dilution:
Flow Cytometry: 1:200-1:400
ELISA: 1:10, 000
Western Blot: 1:500-1:2000
Immunohistochemistry(Paraffin): 1:200-1:1000
Immunocytochemistry: 1:200-1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.