LRRK2 (Leucine-rich Repeat Kinase 2, RIP7, PARK8, Dardarin)

Antibodies / Antibodies-Protein Kinases

-20°C

Supplied as a liquid in Tris-glycine, pH 7.2, 0.05% sodium azide.

A synthetic peptide made to a C-terminal region, within residues 2527-2577 of the human LRRK2 protein, conjugated to KLH. Cellular Localization: Cytoplasm. Membrane; Peripheral membrane protein.

This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a GTPase domain, a kinase domain, and a WD40 domain. The protein is present largely in the cytoplasm, but also associates with lipid membranes. Mutations in this gene have been genetically lined to late-onset, Lewy body Parkinson disease.

Applicatons:
Suitable for use in ELISA, Immunohistochemistry (frozen sections) and Western blot.Other applications have not been tested

Positive Controls:
Human lymphoblasts for IHC and human and mouse brain for Western blot

Storage and Stability:
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.