RANKL (Receptor Activator of Nuclear Factor kappa B Ligand,Receptor Activator of NFkB Ligand,CD254,hRANKL2,hRANKL-2,Osteoclast Differentiation Factor,ODF,Osteoprotegerin Ligand,OPGL,sOdf,SOFA,TNF-related Activation-induc

Antibodies / Antibodies-RANK

-20°C

Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.

Synthetic peptide corresponding to aa161-177 of mouse Trance (AQPFAHLTINAASIPSG), GenBank no. gi|12643362|sp|O35235|TNF11_MOUSE.

RANKL is a recently identified member of tumor necrosis factor family. TRANCE (TNF-related activation-induced cytokine receptor) or RANKL {receptor activator of NF-kB (RANK) ligand} has been implicated in interactions between T cells and dendritic cells. RANK ligand binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival. RANKL is also important in T- and B-cell maturation. As OPGL/ODF (Osteoprotegerin Ligand/Osteoclast differentiation factor), the same protein can both activate mature osteoclasts and mediate osteoclastogenesis. OPGL/TRANCE deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis.

Applications:
Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 0.5ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.