Anti-APP [pT668](polyclonal)

+4°C / -20°C *

Unconjugated

Amyloid protein precursor also called APP (Gene ID: 351) is a type 1 transmembrane protein whose metabolism leads to the production of amyloid-beta peptides. In Alzheimer’s disease, amyloid peptides are the main components of amyloid deposits. Phosphorylation of APP at threonine 668 is increased in Alzheimer’s disease and promotes amyloid-beta peptide production. The threonine 668 is phosphorylated by CDK5 (cyclin dependent kinase 2), JNKs (c-Jun N-terminal kinases) and GSK3 (glycogen synthase kinase 3) and DYRK1A (Dual-specificity tyrosine(Y)-phosphorylation regulated kinase 1A).

Rabbit serum diluted in glycerol with 0.05% sodium azide.