Comparison

Goat Anti-KPNA4 / IPOA3 Antibody

Item no. ABC-AF1604a
Manufacturer Abcepta
Amount 100 ug
Category
Type Antibody Primary
Applications WB, IHC, ELISA
Specific against other
Host Goat
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Similar products KPNA4, QIP1, Importin alpha Q1, Karyopherin subunit alpha-4, Importin subunit alpha-3, Qip1
Available
Primary Accession
O00629
Antigen Type
Synthetic Peptide
Application
WB, IHC, E
Bio Background
The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.
Bio References
Importin alpha3 interacts with HIV-1 integrase and contributes to HIV-1 nuclear import and replication. Ao Z, et al. J Virol, 2010 Sep. PMID 20554775.
Common importin alpha specificity for papillomavirus E2 proteins. Bian XL, et al. Virus Res, 2010 Jun. PMID 20193720.
Stress-mediated nuclear stabilization of p53 is regulated by ubiquitination and importin-alpha3 binding. Marchenko ND, et al. Cell Death Differ, 2010 Feb. PMID 19927155.
Prohibitin inhibits tumor necrosis factor alpha-induced nuclear factor-kappa B nuclear translocation via the novel mechanism of decreasing importin alpha3 expression. Theiss AL, et al. Mol Biol Cell, 2009 Oct. PMID 19710421.
Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite. Singh AP, et al. Cell, 2007 Nov 2. PMID 17981117.
Clonality
Polyclonal
Gene ID
3840
Gene Name
KPNA4
Subtitle
Peptide-affinity purified goat antibody
Reactivity
H, M
Legend image 1
AF1604a staining (0.5 µg/ml) of Human Testis lysate (RIPA buffer, 35 µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
Type image 1
WB
Legend image 2
AF1604a (3 µg/ml) staining of paraffin embedded Human Testis. Microwaved antigen retrieval with citrate buffer pH 6, HRP-staining.
Type image 2
IHC
Legend image 3
AF1604a (5 µg/ml) staining of paraffin embedded Human Small Intestine. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Type image 3
IHC
Other Accession
NP_002259; 3840;
Predicted
Rat, Dog, Cow
Concentration (mg/ml)
100ug/200ul

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ug
Available: In stock
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