Comparison

Goat Anti-NONO / p54NRB Antibody

Item no. ABC-AF1738a
Manufacturer Abcepta
Amount 100 ug
Category
Type Antibody Primary
Applications WB, IHC, ELISA
Specific against other
Host Goat
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Similar products NONO, NRB54, Non-POU domain-containing octamer-binding protein, 54 kDa nuclear RNA- and DNA-binding protein, 55 kDa nuclear protein, DNA-binding p52/p100 complex, 52 kDa subunit, NMT55, p54(nrb), NonO protein, p54nrb
Available
Primary Accession
Q15233
Antigen Type
Synthetic Peptide
Application
WB, IHC, E
Bio Background
This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16.
Bio References
hnRNP M interacts with PSF and p54(nrb) and co-localizes within defined nuclear structures. Marko M, et al. Exp Cell Res, 2010 Feb 1. PMID 19874820.
The hepatitis delta virus RNA genome interacts with eEF1A1, p54(nrb), hnRNP-L, GAPDH and ASF/SF2. Sikora D, et al. Virology, 2009 Jul 20. PMID 19464723.
p54nrb is a transcriptional corepressor of the progesterone receptor that modulates transcription of the labor-associated gene, connexin 43 (Gja1). Dong X, et al. Mol Endocrinol, 2009 Aug. PMID 19423654.
An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles. Clemson CM, et al. Mol Cell, 2009 Mar 27. PMID 19217333.
Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia. Martins-de-Souza D, et al. Eur Arch Psychiatry Clin Neurosci, 2009 Apr. PMID 19165527.
Clonality
Polyclonal
Gene ID
4841
Gene Name
NONO
Subtitle
Peptide-affinity purified goat antibody
Reactivity
H, M
Legend image 1
AF1738a (0.1 µg/ml) staining of mouse brain lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Type image 1
WB
Legend image 2
HEK293 overexpressing Human NONO (RC206688) and probed with AF1738a (mock transfection in first lane), tested by Origene.
Type image 2
WB
Legend image 3
AF1738a (3.8 µg/ml) staining of paraffin embedded Human Spleen. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Type image 3
IHC
Other Accession
NP_031389; 4841; 53610 (mouse); 317259 (rat);
Predicted
Rat, Dog
Concentration (mg/ml)
100ug/200ul

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ug
Available: In stock
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