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Goat Anti-TGM2 Antibody

Goat Anti-TGM2 Antibody

Item no.	ABC-AF2083a
Manufacturer	Abcepta
Amount	100 ug
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Applications	WB, ELISA
Specific against	other
Host	Goat
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	TGM2, Protein-glutamine gamma-glutamyltransferase 2, Tissue transglutaminase, Transglutaminase C, Transglutaminase H, Transglutaminase-2, TGC, TGase C, TGase H, TGase-2, TG(C), 2.3.2.13
Available
Primary Accession	P21980
Antigen Type	Synthetic Peptide
Application	WB, E
Bio Background	Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene.
Bio References	I-kappaBalpha depletion by transglutaminase 2 and mu-calpain occurs in parallel with the ubiquitin-proteasome pathway. Kim DS, et al. Biochem Biophys Res Commun, 2010 Aug 20. PMID 20659425. Redox regulation of transglutaminase 2 activity. Stamnaes J, et al. J Biol Chem, 2010 Aug 13. PMID 20547769. Decreased S-nitrosylation of tissue transglutaminase contributes to age-related increases in vascular stiffness. Santhanam L, et al. Circ Res, 2010 Jul 9. PMID 20489165. Coeliac disease autoantibodies mediate significant inhibition of tissue transglutaminase. Byrne G, et al. Clin Immunol, 2010 Sep. PMID 20488756. Inhibition of tissue transglutaminase sensitizes TRAIL-resistant lung cancer cells through upregulation of death receptor 5. Frese-Schaper M, et al. FEBS Lett, 2010 Jul 2. PMID 20450916.
Clonality	Polyclonal
Gene ID	7052
Gene Name	TGM2 {ECO:0000303\|PubMed:17939176, ECO:0000312\|HGNC:HGNC:11778}
Subtitle	Peptide-affinity purified goat antibody
Reactivity	H
Legend image 1	AF2083a (0.03 µg/ml) staining of Human Lung lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Type image 1	WB
Legend image 2	AF2083a (0.1 µg/ml) staining of A549 lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Type image 2	WB
Other Accession	NP_004604; 7052;
Concentration (mg/ml)	100ug/200ul

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 10/2/2025

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