PAX7 (Rhabdomyosarcoma Marker) Antibody - With BSA and Azide

P23759

The Pax gene family of nuclear transcription factors is comprised of nine members that function during embryogenesis to regulate the temporal and position-dependent differentiation of cells. In addition, the family is involved in a variety of signal transduction pathways in the adult organism. Mutations in the Pax family of proteins have been linked to disease and cancer in humans. Pax-7 is a protein specifically expressed in cultured satellite cell-derived myoblasts. In situ hybridization reveals that Pax-7 is also expressed in satellite cells residing in adult muscle. A chromosomal aberration in the gene encoding Pax-7 causes rhabdomyosarcoma 2 (RMS2) (also called alveolar rhabdomyosarcoma).

5081

Mouse Monoclonal Antibody [Clone SPM613 ]

Formalin-fixed, paraffin-embedded human Rhabdomyosarcoma stained with PAX7 Monoclonal Antibody (SPM613).

5081, 113253