Comparison

Wilm's Tumor 1 (WT1) (Wilm's Tumor & Mesothelial Marker) Antibody - With BSA and Azide

Item no. ABC-AH12530-U0020
Manufacturer Abcepta
Amount 20 ug
Category
Type Antibody Primary
Applications FC, IF, IHC-P
Clone WT1/857
Specific against other
Host Mouse
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Similar products WT1, Wilms tumor protein, WT33
Available
Primary Accession
P19544
Application
IHC-P, IF, FC
Bio Background
Recognizes a 47-55kDa-tumor suppressor protein, identified as Wilm's Tumor (WT1) protein. The antibody reacts with all isoforms of the full-length WT1 and also identifies WT1 lacking exon 2-encoded amino acids, frequently found in subsets of sporadic Wilm s tumors.?WT1, a sporadic and familial pediatric kidney tumor, is genetically heterogeneous. Wilm s tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilm s tumor and mesothelioma. WT1 protein has been identified in proliferative mesothelial cells, malignant mesothelioma, ovarian carcinoma, gonadoblastoma, nephroblastoma, and desmoplastic small round cell tumor. Lung adenocarcinomas rarely stain positive with this antibody. WT1 protein expression in mesothelial cells has become a reliable marker for the diagnosis of mesotheliomas.
Bio References
Rauscher FJ. The WT1 Wilms tumor gene product: A developmentally regulated transcription factor in the kidney that functions as a tumor suppressor. FASEB J 1993; 7:896 |
Clonality
Monoclonal
Gene ID
7490
Gene Name
WT1
Subtitle
Mouse Monoclonal Antibody [Clone WT1/857 ]
Reactivity
H, M, Rat
Legend image 1
Formalin-fixed, paraffin-embedded human Fetal Kidney stained with WT1 Monoclonal Antibody (WT1/857).
Type image 1
IHC
Legend image 2
Formalin-fixed, paraffin-embedded Mouse Kidney stained with WT1 Monoclonal Antibody (WT1/857).
Type image 2
IHC
Legend image 3
Formalin-fixed, paraffin-embedded Rat kidney stained with WT1 Monoclonal Antibody (WT1/857).
Type image 3
IHC
Other Accession
7490, 591980
Clone: WT1/857

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 20 ug
Available: In stock
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