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PAG1 Antibody (aa97-432)

PAG1 Antibody (aa97-432)

Item no.	ABC-ALS12482
Manufacturer	Abcepta
Amount	50 ug
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Applications	WB, IP, IHC-P
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	CBP, PAG1, PAG, Csk-binding protein, Phosphoprotein associated with glycosphingolipid-enriched microdomains 1, Transmembrane adapter protein PAG, Transmembrane phosphoprotein Cbp
Available
Primary Accession	Q9NWQ8
Antigen Type	Recombinant protein
Application	WB, IHC-P, IP
Bio Background	Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
Bio References	Brdicka T., et al.J. Exp. Med. 191:1591-1604(2000). Ota T., et al.Nat. Genet. 36:40-45(2004). Mural R.J., et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. Brdickova N., et al.FEBS Lett. 507:133-136(2001). Brill L.M., et al.Anal. Chem. 76:2763-2772(2004).
Clonality	Polyclonal
Gene ID	55824
Gene Name	PAG1
Subtitle	Rabbit Polyclonal Antibody
Reactivity	H, M
Legend image 1	Anti-PAG1 / PAG antibody IHC of human tonsil.
Type image 1	IHC
Calculated MW	46981
Target/Specificity	Recognizes Csk-binding protein (Cbp / PAG), a 46 kD ubiquitously expressed transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains), which however migrates on SDS PAGE gels anomalously as an 80 kD molecule.
Purification	Precipitation
Concentration (mg/ml)	1 mg/ml
Reconstitution & Storage	+4°C or -20°C, Avoid repeated freezing and thawing.
Dilution	IHC-P (10 µg/ml)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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Delivery expected until 10/2/2025

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