GSTA1 Antibody

NP_665683.1

Cytosolic and membrane-bound forms of glutathione
S-transferase are encoded by two distinct supergene families. These
enzymes function in the detoxification of electrophilic compounds,
including carcinogens, therapeutic drugs, environmental toxins and
products of oxidative stress, by conjugation with glutathione. The
genes encoding these enzymes are known to be highly polymorphic.
These genetic variations can change an individual's susceptibility
to carcinogens and toxins as well as affect the toxicity and
efficacy of some drugs. At present, eight distinct classes of the
soluble cytoplasmic mammalian glutathione S-transferases have been
identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta.
This gene encodes a glutathione S-tranferase belonging to the alpha
class. The alpha class genes, located in a cluster mapped to
chromosome 6, are the most abundantly expressed glutathione
S-transferases in liver. In addition to metabolizing bilirubin and
certain anti-cancer drugs in the liver, the alpha class of these
enzymes exhibit glutathione peroxidase activity thereby protecting
the cells from reactive oxygen species and the products of
peroxidation.

2938

H

HUMAN

NP_665683.1