ANPEP Antibody

Primary Antibodies; Cardiovascular; Cell Biology; Immunology; Signal Transduction; Host cell receptor for virus entry; Viral entry into host cell; Host-virus interaction

Aminopeptidase N is located in the small-intestinal andrenal microvillar membrane, and also in other plasma membranes. Inthe small intestine aminopeptidase N plays a role in the finaldigestion of peptides generated from hydrolysis of proteins bygastric and pancreatic proteases. Its function in proximal tubularepithelial cells and other cell types is less clear. The largeextracellular carboxyterminal domain contains a pentapeptideconsensus sequence characteristic of members of the zinc-bindingmetalloproteinase superfamily. Sequence comparisons with knownenzymes of this class showed that CD13 and aminopeptidase N areidentical. The latter enzyme was thought to be involved in themetabolism of regulatory peptides by diverse cell types, includingsmall intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Humanaminopeptidase N is a receptor for one strain of human coronavirusthat is an important cause of upper respiratory tract infections.Defects in this gene appear to be a cause of various types ofleukemia or lymphoma.

ANPEP

H

HUMAN

WB: 1:500~1000