CST3 Antibody

Primary Antibodies; Cardiovascular; Cell Biology; Signal Transduction

The cystatin superfamily encompasses proteins that containmultiple cystatin-like sequences. Some of the members are activecysteine protease inhibitors, while others have lost or perhapsnever acquired this inhibitory activity. There are three inhibitoryfamilies in the superfamily, including the type 1 cystatins(stefins), type 2 cystatins and the kininogens. The type 2 cystatinproteins are a class of cysteine proteinase inhibitors found in avariety of human fluids and secretions, where they appear toprovide protective functions. The cystatin locus on chromosome 2contains the majority of the type 2 cystatin genes and pseudogenes.This gene is located in the cystatin locus and encodes the mostabundant extracellular inhibitor of cysteine proteases, which isfound in high concentrations in biological fluids and is expressedin virtually all organs of the body. A mutation in this gene hasbeen associated with amyloid angiopathy. Expression of this proteinin vascular wall smooth muscle cells is severely reduced in bothatherosclerotic and aneurysmal aortic lesions, establishing itsrole in vascular disease.

CST3

H

HUMAN

Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Synthetic Peptide