FH Antibody (N-term) (Ascites)

Primary Antibodies; Cancer; Metabolism; Signal Transduction; Mitochondrion

The protein encoded by this gene is an enzymatic componentof the tricarboxylic acid (TCA) cycle, or Krebs cycle, andcatalyzes the formation of L-malate from fumarate. It exists inboth a cytosolic form and an N-terminal extended form, differingonly in the translation start site used. The N-terminal extendedform is targeted to the mitochondrion, where the removal of theextension generates the same form as in the cytoplasm. It issimilar to some thermostable class II fumarases and functions as ahomotetramer. Mutations in this gene can cause fumarase deficiencyand lead to progressive encephalopathy.

FH {ECO:0000303|PubMed:27037871, ECO:0000312|HGNC:HGNC:3700}

H

54637

35-63

WB: 1:100~1600