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CASP3 Antibody

CASP3 Antibody

Item no.	ABC-AM2239b
Manufacturer	Abcepta
Amount	400 ul
Category	Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Antibodies Cell Biology Cell Status Apoptosis Western Blot Primary Antibodies
Type	Antibody Monoclonal
Applications	WB
Clone	1262CT521.280.101
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1
Citations	Choudhary C., et al. Science 325:834-840(2009). Fernandes-Alnemri T., et al. J. Biol. Chem. 269:30761-30764(1994). Tewari M., et al. Cell 81:801-809(1995). Pelletier M., et al. Biochem. Biophys. Res. Commun. 316:93-99(2004). Ota T., et al. Nat. Genet. 36:40-45(2004).
NCBI	NP_004337.2,NP_116786.1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Caspase-3,CASP-3,Apopain,Cysteine protease CPP32,CPP-32,Protein Yama,SREBP cleavage activity 1,SCA-1,Caspase-3 subunit p17,Caspase-3 subunit p12,CASP3,CPP32
Similar products	CASP3, CPP32, Caspase-3, Apopain, Cysteine protease CPP32, Protein Yama, SREBP cleavage activity 1, Caspase-3 subunit p17, Caspase-3 subunit p12, CASP-3, CPP-32, SCA-1
Available
Manufacturer - Category	Crown Antibodies; Primary Antibodies; Antibody Collections; Cancer; Cell Biology; Metabolism; Neuroscience; Amyotrophic Lateral Sclerosis (ALS); Apoptosis; Apoptosis signaling
Manufacturer - Targets	Purified His-tagged CASP3 protein was used to produced this monoclonal antibody.
Bio Background	Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
Clonality	Monoclonal
Gene Name	CASP3
Subtitle	Mouse Monoclonal Antibody (Mab)
Reactivity	H
Calculated Molecular Weight	31608
Antigen Source	Human
Formulation	Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Dilution	WB: 1:2000
Antigen Type	Recombinant Protein

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 1/1/2026

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