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IKK beta Antibody

IKK beta Antibody

Item no.	ABC-AM8109b-ev
Manufacturer	Abcepta
Amount	80 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Applications	WB
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	IKBKB, IKKB, Inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B kinase 2, Nuclear factor NF-kappa-B inhibitor kinase beta, IKK-beta, IKK2, NFKBIKB, IkBKB, I-kappa-B-kinase beta, IKK-B
Available
Primary Accession	O14920
Antigen Type	Recombinant Protein
Application	WB
Bio Background	NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).
Bio References	Downregulation of active IKK beta by Ro52-mediated autophagy. Niida M, et al. Mol Immunol, 2010 Aug. PMID 20627395. Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. Schuurhof A, et al. Pediatr Pulmonol, 2010 Jun. PMID 20503287. Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways. Potter C, et al. Ann Rheum Dis, 2010 Jul. PMID 20448286. Protein phosphatase 2A acts as a mitogen-activated protein kinase kinase kinase 3 (MEKK3) phosphatase to inhibit lysophosphatidic acid-induced IkappaB kinase beta/nuclear factor-kappaB activation. Sun W, et al. J Biol Chem, 2010 Jul 9. PMID 20448038. Respiratory syncytial virus-mediated NF-kappa B p65 phosphorylation at serine 536 is dependent on RIG-I, TRAF6, and IKK beta. Yoboua F, et al. J Virol, 2010 Jul. PMID 20410276.
Clonality	Monoclonal
Clone/Animal Names	62AT992
Gene ID	3551
Gene Name	IKBKB
Subtitle	Purified Mouse Monoclonal Antibody (Mab)
Reactivity	H
Legend image 1	The anti-IKKbeta Mab (Cat. #AM8109b) is used in Western blot to detect IKKbeta in SK-BR3 cell lysate.
Type image 1	WB
Dilution image 1	1:500~1000
Isotype	Mouse IgG1
Calculated MW	86564
Antigen Source	HUMAN
Target/Specificity	This IKK beta antibody was raised using purified His-tagged recombinant full length human IKK beta.
NCBI Accession	NP_001177649.1; NP_001229707.1; NP_001547.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 80 ul

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Delivery expected until 9/4/2025

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