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ULK3 Antibody (C-term)

ULK3 Antibody (C-term)

Item no.	ABC-AM8437c
Manufacturer	Abcepta
Amount	400 ul
Category	Antibodies Cell Biology Cell Status Western Blot Autophagy Primary Antibodies
Type	Antibody Monoclonal
Applications	WB
Clone	1404CT148.89.25
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Mouse
Isotype	IgG1 Kappa
Citations	Ota T.,et al.Nat. Genet. 36:40-45(2004). Bechtel S.,et al.BMC Genomics 8:399-399(2007). Zody M.C.,et al.Nature 440:671-675(2006). Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. Daub H.,et al.Mol. Cell 31:438-448(2008).
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Serine/threonine-protein kinase ULK3,Unc-51-like kinase 3,ULK3
Similar products	ULK3, Serine/threonine-protein kinase ULK3, Unc-51-like kinase 3
Available
Manufacturer - Category	Crown Antibodies; Primary Antibodies; Signal Transduction; Autophagy; Regulation of autophagy
Manufacturer - Targets	This ULK3 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 435-468 amino acids from the C-terminal region of human ULK3.
Bio Background	Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
Clonality	Monoclonal
Gene Name	ULK3
Subtitle	Purified Mouse Monoclonal Antibody (Mab)
Reactivity	H, M, Rat
Calculated Molecular Weight	53444
Antigen Source	HUMAN
Formulation	Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
Dilution	IHC: 1:50 WB: 1:1000

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 1/1/2026

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