MB21D1 Antibody

Crown Antibodies; Primary Antibodies; Cell Biology; Antiviral defense; Immunity; Inflammasome; Innate immunity; Immune system process

Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2', 5' phosphodiester linkage at the GpA step and the formation of a 3', 5' phosphodiester linkage at the ApG step, producing c[G(2', 5')pA(3', 5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double- stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.

CGAS {ECO:0000303|PubMed:23258413, ECO:0000312|HGNC:HGNC:21367}

H

HUMAN

WB: 1:4000