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Dnmt3a Antibody

Dnmt3a Antibody

Item no.	ABC-AM8628b-ev-50ul
Manufacturer	Abcepta
Amount	50 ul
Category	Oncology Neuroscience Neural Epigenetics Antibodies Carcinoma Hematology Leukemia Lymphoma Melanoma Sarcoma Western Blot Primary Antibodies
Type	Antibody Monoclonal
Applications	Western Blot
Specific against	other
Host	Mouse
Isotype	IgG1 kappa
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	DNA (cytosine-5)-methyltransferase 3A, Dnmt3a, 2.1.1.37, DNA methyltransferase HsaIIIA, DNA MTase HsaIIIA, M.HsaIIIA, DNMT3A
Available
Primary Accession	Q9Y6K1
Antigen Type	Recombinant Protein
Bio Background	Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.
Bio References	Xie S., et al.Gene 236:87-95(1999). Chen T., et al.J. Biol. Chem. 277:38746-38754(2002). Kim G.-D., et al.EMBO J. 21:4183-4195(2002). Hillier L.W., et al.Nature 434:724-731(2005). Mural R.J., et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Gene ID	1788
Gene Name	DNMT3A
Reactivity	H
Calculated MW	101858
Antigen Source	HUMAN
Target/Specificity	This Dnmt3a antibody is generated from a mouse immunized with a recombinant protein of human Dnmt3a.

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Amount: 50 ul

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