Nicotinic Acetylcholine Receptor (nAChR) b4 Antibody

Q8R493

Nicotinic acetylcholine receptors (nAChRs) are ionotropic, cholinergic receptors that are divided into 2 types; muscle type and neuronal type. Neuronal nAChRs are pentameric ion channels consisting of 5 identical (homopentamers) or different (heteropentamers) subunits. Heteropentameric neuronal nAChRs mediate fast synaptic transmission in the autonomic nervous system. The predominant hetero-oligomeric nAChR in the CNS contain the subunits ?4?2, whereas ?3?4 prevail in the PNS. However, the expression of these subunits varies not only by region but also during development (Scholze et al 2011). In the brain, ?2-containing receptors greatly outnumber receptors that contain ?4 (

108015

Rabbit Polyclonal Antibody

Western blot of mouse habenula lysate showing specific immunolabeling of the ~52 kDa nAChR?4 protein.

1:1000

Fusion protein from the cytoplasmic loop of the beta 4 subunit of rat nAChR