CASP3 Antibody (C-term)

Primary Antibodies; Antibody Collections; Cancer; Cell Biology; Metabolism; Neuroscience; Amyotrophic Lateral Sclerosis (ALS); Apoptosis; Apoptosis signaling

This gene encodes a protein which is a member of thecysteine-aspartic acid protease (caspase) family. Sequentialactivation of caspases plays a central role in the execution-phaseof cell apoptosis. Caspases exist as inactive proenzymes whichundergo proteolytic processing at conserved aspartic residues toproduce two subunits, large and small, that dimerize to form theactive enzyme. This protein cleaves and activates caspases 6, 7 and9, and the protein itself is processed by caspases 8, 9 and 1. Itis the predominant caspase involved in the cleavage of amyloid-beta4A precursor protein, which is associated with neuronal death inAlzheimer's disease. Alternative splicing of this gene results intwo transcript variants that encode the same protein. [provided byRefSeq].

RB14883

Purified Rabbit Polyclonal Antibody (Pab)

Pr, M, Rb, Rat

HUMAN

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Synthetic Peptide