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TRIM72 Antibody (C-term)

TRIM72 Antibody (C-term)

Item no.	ABC-AP11980b
Manufacturer	Abcepta
Amount	400 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	MG53, Tripartite motif-containing protein 72, Mitsugumin-53, Mg53, TRIM72 (HGNC:32671)
Available
Primary Accession	Q6ZMU5
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	TRIM72 is a muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).
Bio References	Park, E.Y., et al. Proteins 78(3):790-795(2010) Han, S., et al. Hum. Mol. Genet. 18(6):1171-1180(2009) Martin, J., et al. Nature 432(7020):988-994(2004)
Clonality	Polyclonal
Clone/Animal Names	RB29696
Gene ID	493829
Gene Name	TRIM72 (HGNC:32671)
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M, Rat
Legend image 1	All lanes : Anti-TRIM72 Antibody (C-term) at 1:2000 dilution Lane 1: HCT116 whole cell lysate Lane 2: human skeletal muscle lysate Lane 3: mouse skeletal muscle lysate Lane 4: rat skeletal muscle lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 53 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Type image 1	WB
Dilution image 1	1:2000
Legend image 2	TRIM72 Antibody (C-term) (Cat. #AP11980b)immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TRIM72 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Type image 2	IHC-P
Dilution image 2	1:10~50
Other Accession	NP_001008275.2
Isotype	Rabbit Ig
Calculated MW	52731
Antigen Region	299-327
Antigen Source	HUMAN
Target/Specificity	This TRIM72 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 299-327 amino acids from the C-terminal region of human TRIM72.
NCBI Accession	NP_001008275.2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 11/6/2025

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