« Back
Home /
GREM1 Antibody (C-term)

GREM1 Antibody (C-term)

Item no.	ABC-AP12247b-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Neuroscience Neural Signaling Antibodies Cell Biology Cell Status Western Blot Proliferation Primary Antibodies
Type	Antibody Polyclonal
Applications	Western Blot
Clone	RB57742
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Gremlin-1, Cell proliferation-inducing gene 2 protein, Cysteine knot superfamily 1, BMP antagonist 1, DAN domain family member 2, Down-regulated in Mos-transformed cells protein, Increased in high glucose protein 2, IHG-2, GREM1, CKTSF1B1, DAND2, DRM
Available
Primary Accession	O60565
Other Accession	O35793; O70326; NP_037504.1
Antigen Type	Synthetic Peptide
Bio Background	This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Bio References	Kupfer, S.S., et al. Gastroenterology 139(5):1677-1685(2010) Dimitrov, B.I., et al. J. Med. Genet. 47(8):569-574(2010) McKnight, A.J., et al. J. Am. Soc. Nephrol. 21(5):773-781(2010) van Vlodrop, I.J., et al. Am. J. Pathol. 176(2):575-584(2010) Mangold, E., et al. Nat. Genet. 42(1):24-26(2010)
Gene ID	26585
Gene Name	GREM1
Reactivity	H
Predicted	M, Rat
Calculated MW	20697
Antigen Region	111-139
Antigen Source	HUMAN
Target/Specificity	This GREM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-139 amino acids from the C-terminal region of human GREM1.
NCBI Accession	NP_001178252.1; NP_037504.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

ABC-AP12247b-ev-80ul-datasheet.pdf

Request safety datasheet

Simple Order Order Subscription

Amount: 80 ul

not available