GNE Antibody (N-term)

Synthetic Peptide

The protein encoded by this gene is a bifunctional enzyme
that initiates and regulates the biosynthesis of N-acetylneuraminic
acid (NeuAc), a precursor of sialic acids. It is a rate-limiting
enzyme in the sialic acid biosynthetic pathway. Sialic acid
modification of cell surface molecules is crucial for their
function in many biologic processes, including cell adhesion and
signal transduction. Differential sialylation of cell surface
molecules is also implicated in the tumorigenicity and metastatic
behavior of malignant cells. Mutations in this gene are associated
with sialuria, autosomal recessive inclusion body myopathy, and
Nonaka myopathy. Alternative splicing of this gene results in
transcript variants encoding different isoforms. [provided by
RefSeq].

Polyclonal

10020

Affinity Purified Rabbit Polyclonal Antibody (Pab)

GNE Antibody (N-term) (Cat. #AP12285a) western blot analysis in human placenta tissue lysates (35ug/lane).This demonstrates the GNE antibody detected the GNE protein (arrow).

1:1000

IHC-P

O35826; Q91WG8; Q7TQ49; NP_001121699.1; NP_005467.1

Rabbit Ig

169-197

This GNE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 169-197 amino acids from the N-terminal region of human GNE.