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PIAS2 (PIASx1/2) Antibody (N-term)

PIAS2 (PIASx1/2) Antibody (N-term)

Item no.	ABC-AP1246a-ev-80ul
Manufacturer	Abcepta
Amount	80 ul
Category	Oncology Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Antibodies Carcinoma Obesity Immunohistochemistry Western Blot Enzymes Fatty Acid Synthesis Primary Antibodies
Type	Antibody Polyclonal
Applications	Western Blot, Immunohistochemistry
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	E3 SUMO-protein ligase PIAS2, 632-, Androgen receptor-interacting protein 3, ARIP3, DAB2-interacting protein, DIP, Msx-interacting zinc finger protein, Miz1, PIAS-NY protein, Protein inhibitor of activated STAT x, Protein inhibitor of activated STAT2, PIA
Available
Primary Accession	O75928
Other Accession	Q6AZ28; Q8C5D8
Antigen Type	Synthetic Peptide
Bio Background	PIASX functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. This protein plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. PIASX binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha.
Bio References	Arora, T., et al., J. Biol. Chem. 278(24):21327-21330 (2003). Wu, S., et al., Oncogene 22(3):351-360 (2003). Liu, B., et al., Proc. Natl. Acad. Sci. U.S.A. 95(18):10626-10631 (1998). Wu, L., et al., Mech. Dev. 65 (1-2), 3-17 (1997).
Gene ID	9063
Gene Name	PIAS2
Reactivity	H
Predicted	M, Rat
Calculated MW	68240
Antigen Region	109-140
Antigen Source	HUMAN
Target/Specificity	This PIAS2 (PIASx1/2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 109-140 amino acids from the N-terminal region of human PIAS2 (PIASx1/2).
NCBI Accession	NP_004662.2; NP_775298.1

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Amount: 80 ul

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