CAPN6 Antibody (Center)

Primary Antibodies; Cell Biology; Signal Transduction

Calpains are ubiquitous, well-conserved family ofcalcium-dependent, cysteine proteases. The calpain proteins areheterodimers consisting of an invariant small subunit and variablelarge subunits. The large subunit possesses a cysteine proteasedomain, and both subunits possess calcium-binding domains. Calpainshave been implicated in neurodegenerative processes, as theiractivation can be triggered by calcium influx and oxidative stress.The protein encoded by this gene is highly expressed in theplacenta. Its C-terminal region lacks any homology to thecalmodulin-like domain of other calpains. The protein lackscritical active site residues and thus is suggested to beproteolytically inactive. The protein may play a role in tumorformation by inhibiting apoptosis and promoting angiogenesis.

RB19561

Affinity Purified Rabbit Polyclonal Antibody (Pab)

M, Rat

HUMAN

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Synthetic Peptide