MRPS12 Antibody (Center K43)

NP_203526.1; NP_066930.1

Mammalian mitochondrial ribosomal proteins are encoded by
nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
small 28S subunit and a large 39S subunit. They have an estimated
75% protein to rRNA composition compared to prokaryotic ribosomes,
where this ratio is reversed. Another difference between mammalian
mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the
mitoribosome differ greatly in sequence, and sometimes in
biochemical properties, which prevents easy recognition by sequence
homology. This gene encodes a 28S subunit protein that belongs to
the ribosomal protein S12P family. The encoded protein is a key
component of the ribosomal small subunit and controls the decoding
fidelity and susceptibility to aminoglycoside antibiotics. The gene
for mitochondrial seryl-tRNA synthetase is located upstream and
adjacent to this gene, and both genes are possible candidates for
the autosomal dominant deafness gene (DFNA4). Splice variants that
differ in the 5' UTR have been found for this gene; all three
variants encode the same protein.

6183

H

28-59

This MRPS12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-59 amino acids from the Central region of human MRPS12.