Comparison

RAP1A Antibody (C-term)

Item no. ABC-AP12949B-ev-80ul
Manufacturer Abcepta
Amount 80 ul
Category
Type Antibody Polyclonal
Applications Western Blot
Specific against other
Host Rabbit
Isotype Ig
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Ras-related protein Rap-1A, C21KG, G-22K, GTP-binding protein smg p21A, Ras-related protein Krev-1, RAP1A, KREV1
Available
Primary Accession
P62834
Other Accession
A6NIZ1; Q7ZXH7; Q62636; Q99JI6; Q4R9D4; P61224; Q6TEN1; Q5ZHX1; P61223; P62836; P62835; P62833; NP_001010935.1; NP_002875.1
Antigen Type
Synthetic Peptide
Bio Background
The product of this gene belongs to the family of
RAS-related proteins. These proteins share approximately 50% amino
acid identity with the classical RAS proteins and have numerous
structural features in common. The most striking difference between
RAP proteins and RAS proteins resides in their 61st amino acid:
glutamine in RAS is replaced by threonine in RAP proteins. The
product of this gene counteracts the mitogenic function of RAS
because it can interact with RAS GAPs and RAF in a competitive
manner. Two transcript variants encoding the same protein have been
identified for this gene.
Bio References
Liu, C., et al. Mol. Cell. Biol. 30(16):3956-3969(2010)
Kelly, P., et al. J. Biol. Chem. 285(21):15777-15785(2010)
Ahmed, S.M., et al. J. Biol. Chem. 285(9):6538-6551(2010)
Hsu, Y.H., et al. PLoS Genet. 6 (6), E1000977 (2010) :
Sarthy, J., et al. EMBO J. 28(21):3390-3399(2009)
Gene ID
5906
Gene Name
RAP1A
Reactivity
M
Predicted
B, Rat, C, Zf, H, Pr, X
Calculated MW
20987
Antigen Region
142-170
Antigen Source
HUMAN
Target/Specificity
This RAP1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 142-170 amino acids from the C-terminal region of human RAP1A.
NCBI Accession
NP_001010935.1; NP_002875.1

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