GRM6 Antibody (Center)

Synthetic Peptide

L-glutamate is the major excitatory neurotransmitter in
the central nervous system and activates both ionotropic and
metabotropic glutamate receptors. Glutamatergic neurotransmission
is involved in most aspects of normal brain function and can be
perturbed in many neuropathologic conditions. The metabotropic
glutamate receptors are a family of G protein-coupled receptors,
that have been divided into 3 groups on the basis of sequence
homology, putative signal transduction mechanisms, and
pharmacologic properties. Group I includes GRM1 and GRM5 and these
receptors have been shown to activate phospholipase C. Group II
includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7
and GRM8. Group II and III receptors are linked to the inhibition
of the cyclic AMP cascade but differ in their agonist
selectivities.

Polyclonal

2916

Affinity Purified Rabbit Polyclonal Antibody (Pab)

GRM6 Antibody (Center) (Cat. #AP13735c) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the GRM6 antibody detected the GRM6 protein (arrow).

1:1000

Rabbit Ig

369-398

This GRM6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 369-398 amino acids from the Central region of human GRM6.