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Mouse Dyrk2 Antibody (C-term)

Mouse Dyrk2 Antibody (C-term)

Item no.	ABC-AP14070B
Manufacturer	Abcepta
Amount	400 ul
Category	Antibodies Primary Antibodies
Type	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applications	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	Dual specificity tyrosine-phosphorylation-regulated kinase 2, Dyrk2 {ECO:0000312\|MGI:MGI:1330301}
Available
Primary Accession	Q5U4C9
Antigen Type	Synthetic Peptide
Application	WB, IHC-P
Bio Background	Role in the regulation of cellular growth and/or development. Regulates TP53 by phosphorylation on Ser-46 to induce apoptosis in response to DNA damage, functioning downstream of ATM. Inactivates GYS1 by phosphorylation at Ser-641, and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Phosphorylates EIF2B5 at Ser-544, enabling its subsequent phosphorylation and inhibition by GSK3, and may play a more general role in the priming of GSK3 substrates (By similarity).
Bio References	Guo, X., et al. J. Biol. Chem. 285(17):13223-13232(2010) Kudo, L.C., et al. Cereb. Cortex 17(9):2108-2122(2007) Blackshaw, S., et al. PLoS Biol. 2 (9), E247 (2004) : Clark, A.G., et al. Science 302(5652):1960-1963(2003) Geiger, J.N., et al. Blood 97(4):901-910(2001)
Clonality	Polyclonal
Clone/Animal Names	RB34467
Gene ID	69181
Gene Name	Dyrk2 {ECO:0000312\|MGI:MGI:1330301}
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M
Legend image 1	All lanes : Anti-Dyrk2 Antibody (C-term) at 1:2000 dilution Lane 1: CCRF-CEM whole cell lysate Lane 2: HepG2 whole cell lysate Lane 3: K562 whole cell lysate Lane 4: Ba/F3 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 67 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Type image 1	WB
Dilution image 1	1:2000
Legend image 2	Mouse Dyrk2 Antibody (C-term) (Cat. #AP14070b) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the Dyrk2 antibody detected the Dyrk2 protein (arrow).
Type image 2	WB
Dilution image 2	1:1000
Legend image 3	All lanes : Anti-Mouse Dyrk2 Antibody (C-term) at 1:8000 dilution Lane 1: Hela whole cell lysate Lane 2: HepG2 whole cell lysate Lane 3: SK-OV-3 whole cell lysate Lane 4: C2C12 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 67 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Type image 3	WB
Dilution image 3	1:8000
Legend image 4	AP14070b staining Dyrk2 in human testis tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Samples were incubated with primary antibody (1/100) for 1 hours at room temperature. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody.
Type image 4	IHC-P
Dilution image 4	1:100
Other Accession	NP_001014412.1
Isotype	Rabbit Ig
Calculated MW	66556
Antigen Region	521-549
Antigen Source	MOUSE
Target/Specificity	This Mouse Dyrk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 521-549 amino acids from the C-terminal region of mouse Dyrk2.
NCBI Accession	NP_001014412.1

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 10/2/2025

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